Leo E Otterbein Selected Research

Biliverdine (Biliverdin)

1/2013	Biliverdin protects against liver ischemia reperfusion injury in swine.
11/2011	Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase.
12/2005	Biliverdin administration protects against endotoxin-induced acute lung injury in rats.
8/2005	Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation.
2/2005	Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both.
1/2005	Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion.
8/2004	Biliverdin protects the functional integrity of a transplanted syngeneic small bowel.
8/2003	Heme oxygenase-1: unleashing the protective properties of heme.

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Leo E Otterbein Research Topics

Disease

29	Inflammation (Inflammations) 01/2022 - 02/2003
13	Reperfusion Injury 01/2018 - 04/2002
12	Wounds and Injuries (Trauma) 12/2023 - 08/2004
11	Hypoxia (Hypoxemia) 01/2020 - 03/2004
10	Ischemia 10/2023 - 01/2003
9	Neoplasms (Cancer) 05/2024 - 07/2008
8	Lung Injury 10/2023 - 01/2003
6	Colitis 01/2022 - 12/2005
5	Pneumonia (Pneumonitis) 12/2023 - 12/2005
5	Infections 12/2023 - 07/2008
4	Hyperplasia 03/2007 - 08/2003
4	Asthma (Bronchial Asthma) 12/2003 - 04/2002
3	Neointima 01/2021 - 08/2005
3	Sepsis (Septicemia) 10/2020 - 09/2003
3	Endotoxemia 01/2019 - 05/2004
3	Hyperoxia 12/2017 - 07/2003
3	Hemorrhagic Shock 02/2015 - 06/2005
3	Retinoblastoma (Glioblastoma, Retinal) 06/2011 - 08/2005
3	Edema (Dropsy) 11/2004 - 05/2004
2	Breast Neoplasms (Breast Cancer) 05/2024 - 08/2011
2	Lung Neoplasms (Lung Cancer) 12/2023 - 04/2016
2	Bacterial Infections (Bacterial Infection) 10/2021 - 11/2014
2	Coinfection 01/2020 - 01/2015
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2020 - 09/2003
2	Sickle Cell Anemia (Hemoglobin S Disease) 01/2018 - 06/2017
2	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2017 - 07/2015
2	Vascular System Injuries 05/2014 - 02/2010
2	Prostatic Neoplasms (Prostate Cancer) 12/2013 - 07/2008
2	Pathologic Constriction (Stenosis) 02/2010 - 02/2003
2	Shock 08/2009 - 05/2004
2	Acute Lung Injury 05/2006 - 12/2005
2	Ileus 06/2005 - 02/2003
1	Cardiotoxicity 05/2024
1	Neurofibrosarcoma (MPNST) 01/2023
1	Arteriosclerosis 01/2021
1	Acute Kidney Injury (Acute Renal Failure) 01/2020
1	Crohn Disease (Crohn's Disease) 11/2018

Drug/Important Bio-Agent (IBA)

45	Carbon MonoxideIBA 05/2024 - 11/2002
20	Heme Oxygenase-1IBA 04/2016 - 07/2003
12	Heme (Haem)IBA 10/2021 - 02/2003
11	CytokinesIBA 10/2020 - 04/2002
9	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 01/2020 - 02/2003
9	EnzymesIBA 11/2018 - 02/2003
8	Biliverdine (Biliverdin)IBA 01/2013 - 08/2003
6	BilirubinIBA 11/2018 - 08/2003
5	LipopolysaccharidesIBA 01/2019 - 07/2003
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2003
4	Interleukin-10 (Interleukin 10)IBA 04/2013 - 02/2003
4	EndotoxinsIBA 11/2011 - 04/2002
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2010 - 04/2002
3	Peptides (Polypeptides)IBA 01/2023 - 01/2013
3	Oxygen (Dioxygen)IBA 01/2023 - 10/2006
3	Therapeutic UsesIBA 11/2018 - 05/2011
3	Hemoglobins (Hemoglobin)IBA 06/2017 - 03/2004
3	Mitogen-Activated Protein KinasesIBA 04/2016 - 12/2003
3	Adenosine Triphosphate (ATP)IBA 06/2015 - 07/2004
3	Transcription Factors (Transcription Factor)IBA 06/2015 - 12/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2008 - 11/2004
2	Phosphotransferases (Kinase)IBA 12/2023 - 07/2003
2	Caspase 3 (Caspase-3)IBA 10/2023 - 01/2003
2	p38 Mitogen-Activated Protein KinasesIBA 10/2023 - 01/2003
2	salicylhydroxamic acid (SHAM)IBA 01/2023 - 02/2015
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 11/2018 - 06/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2016 - 09/2003
2	Mitochondrial DNA (mtDNA)IBA 01/2015 - 01/2013
2	Free RadicalsIBA 12/2013 - 02/2003
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2011 - 09/2006
2	Messenger RNA (mRNA)IBA 07/2008 - 11/2004
2	Oxidants (Oxidizing Agents)IBA 10/2006 - 12/2003
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 03/2006 - 11/2004
1	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2024
1	AnthracyclinesIBA 05/2024
1	Cardiotonic Agents (Cardiac Stimulants)IBA 05/2024
1	GTP-Binding Proteins (G-Protein)IBA 12/2023
1	CortactinIBA 12/2023
1	Complement System Proteins (Complement)IBA 01/2023
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2023
1	LeukotrienesIBA 01/2023
1	ChemokinesIBA 01/2023
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2022
1	Cisplatin (Platino)FDA LinkGeneric 01/2020
1	Dextran SulfateIBA 11/2018
1	Ritonavir (Norvir)FDA Link 11/2018
1	LigandsIBA 11/2018
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 11/2018
1	Chemotactic FactorsIBA 11/2018

Therapy/Procedure

8	Therapeutics 12/2023 - 06/2005
8	Transplantation 01/2021 - 02/2003
4	Organ Transplantation 01/2018 - 09/2010
3	Drug Therapy (Chemotherapy) 01/2023 - 12/2013
3	Cardiopulmonary Bypass (Heart-Lung Bypass) 12/2017 - 07/2004
2	Resuscitation 02/2015 - 06/2005
2	Hepatectomy 07/2013 - 06/2011
2	Kidney Transplantation 02/2005 - 11/2004
1	Radiotherapy 01/2023
1	Microbubbles 01/2023
1	Hyperbaric Oxygenation 01/2023
1	Injections 01/2019
1	Ligation 11/2018